VITAL SIGNS

The newsletter that separates health signal from noise.

Every week, Vital Signs cuts through the noise in health, biotech, and longevity. Bringing you what actually matters. The trials, the science, the shifts that will affect how you live.

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Thyroid
TSH alone misses 40% of thyroid dysfunction. T3 and T4 tell a completely different story.
Vitamin D
70% of Northern Europeans are deficient by October. Most never test before supplementing.
Inflammation
hs-CRP below 1 mg/L is the cardiovascular risk threshold most standard panels never measure.
Cortisol
A single morning blood draw is one of the least reliable ways to assess HPA axis function.
Iron
Ferritin can look normal while your cells are running on empty. Serum iron tells you nothing.
Cholesterol
ApoB predicts cardiovascular risk more accurately than LDL. Most GPs never order it.
Metabolism
Insulin resistance starts a decade before fasting glucose crosses the diagnostic threshold.
Longevity
Biological age and chronological age can diverge by over a decade — in either direction.
Sleep
One night of poor sleep raises cortisol, suppresses testosterone, and elevates inflammatory markers.
Brain
Low ferritin is the most common and most overlooked cause of persistent brain fog in women under 45.
Hormones
Free testosterone matters more than total testosterone. The ratio shifts significantly with age and stress.
Gut
Chronic low-grade inflammation often starts in the gut — and shows up first in hs-CRP, not symptoms.

Not guesswork. Not trends.
Your biology, explained.

Most health content tells you what to do. We tell you why. Backed by research, written for people who want to understand their own data.

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The science, simplified

Peer-reviewed research translated into what it actually means for how you feel, perform, and age.

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Biomarker breakdowns

Deep dives on the markers your GP never mentions, and why normal doesn't mean optimal.

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Zero hype. Just signal.

No supplement ads. No biohacker bro culture. Just precise, honest health intelligence to help you grow.

One inbox.
Every angle of your health.

An example of what lands in your inbox.

Your health data just became Europe's business

Your health data is going European: here's what that actually means for you. Learn all about pseudonymized health data and its portability introduced by the European Health Data Space (EHDS) in March 2025.
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Everyone's injecting peptides. Here's what they actually are.

Your gym buddy is injecting something called BPC-157. Your favorite longevity influencer swears by thymosin alpha-1. And the U.S. health secretary just promised to "end the war on peptides." But most people couldn't tell you what a peptide actually is. This week, we fix that.
Read post

Here's even more topics that we cover:

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Longevity
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Blood biomarkers
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Thyroid health
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Cortisol & stress
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Inflammation
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Sleep science
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Metabolic health
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Vitamin D
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Cardiovascular risk
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Hormones
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Gut health
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Cognitive performance
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Preventive testing
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Supplements

Written with you, not just for you.

If something in an issue resonates, or if you think we got something wrong,  we want to hear it. Simply reply directly to any email. We read every response.

The questions subscribers ask most often become the next issue. The pushback sharpens our thinking. That feedback loop is how this stays honest.    

  • If you've had your own biomarkers tested and want to share what you found, what surprised you, what changed, what you wish you'd known earlier, those stories are genuinely useful to other readers. You don't need to be an expert.
  • If you're a clinician, researcher, or practitioner who wants to flag something we've covered inaccurately or incompletely, we actively welcome that.
  • Getting things right matters more to us than being first. A short email is enough. We'll credit corrections openly and update where needed.

Your future self
is reading this already.

Every week Vital Signs gives you the small drops of knowledge to stop guessing, and start optimising.

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