Apolipoprotein A1 (ApoA1)

The main protein in HDL, the protective cholesterol particle.

Last reviewedJune 16, 2026

Serum

sample type

~5 mL

blood needed

~7 days

results in app

Any time of day

best timing

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Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

Apolipoprotein A1, or ApoA1, is the main protein in HDL, the lipoprotein often called "good" cholesterol. It helps HDL pull excess cholesterol out of cells and artery walls and carry it back to the liver for removal, a process called reverse cholesterol transport.

Measuring ApoA1 reflects how well this protective HDL system is built, since each HDL particle carries ApoA1.

Heart & Cholesterol

Reviewed against DGKL reference practice.

Why test this?

Higher ApoA1 generally points to a stronger protective lipid profile, while low ApoA1 is linked to lower HDL function and higher cardiovascular risk. It is sometimes used together with ApoB as a ratio, where a favorable ApoB to ApoA1 balance suggests lower risk.

Low ApoA1 can also appear in some inherited conditions and in states of inflammation or poor metabolic health.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult guidance values (guidance only, vary by lab):

Sex	Apolipoprotein A1
Women	roughly 1.25 to 2.15 g/L
Men	roughly 1.10 to 2.05 g/L

Higher values are generally more favorable. Ranges differ between assays.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

You learn how strong your protective HDL system is and, when read with ApoB, how the balance of harmful and protective particles looks. This supports a personalized action plan around diet, exercise, and metabolic health.

What can affect this result?

What can skew the result

Acute illness, inflammation, and pregnancy can shift the value. Alcohol and some medications, including statins and oestrogens, can raise ApoA1. Very high triglycerides can affect some assays.

Best interpreted with

Best read alongside HDL cholesterol, apolipoprotein B, and the ApoB to ApoA1 ratio.

How is this tested?

Sample

Serum

Blood needed

~5 mL

Method

Immunoassay (immunoturbidimetry)

Best timing

Any time of day

Sources. The evidence behind this

LOINC 1869-7: Apolipoprotein A-I in Serum or Plasma

Mayo Clinic Laboratories: Apolipoprotein A1, Serum

Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin (DGKL)

Common questions

Which Aniva panels include this marker?

Heart Health Advanced

These tests assess cholesterol particles and heart-risk markers beyond standard lipid panels.