1-Methylhistidine

A metabolite linked to dietary protein and muscle turnover.

Last reviewedJune 16, 2026

Plasma

sample type

~5 mL

blood needed

~7 days

results in app

Morning, fasting

best timing

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On this page

Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

1-Methylhistidine is a modified amino acid. It comes mainly from anserine, a compound found in the muscle of animals such as poultry and fish. When you eat these foods, anserine is broken down and 1-methylhistidine is released into the blood and passed out in urine.

Comprehensive Health Check

Reviewed against DGKL reference practice.

Why test this?

It is measured as part of a plasma amino acid profile, usually as a marker of recent meat or fish intake rather than of a disease. A high level most often reflects diet. It can occasionally help explain an unusual pattern on the wider amino acid panel.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Group	Adult fasting plasma range
Adults	0 to 22 µmol/L

Amino acid ranges vary by laboratory and method. They are best read as part of the full plasma amino acid profile, not in isolation.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

A picture of recent dietary intake of meat and fish, which can affect other readings.
Context for interpreting the rest of your amino acid profile.
Reassurance that a raised value is usually diet related, not a sign of illness.

What can affect this result?

What can skew the result

Recent intake of meat or fish, overall protein intake, fasting state, and time of day all affect the result. A fasting morning sample gives the most reliable reading.

Best interpreted with

Read as part of the full plasma amino acid profile.

How is this tested?

Sample

Plasma

Blood needed

~5 mL

Method

Ion-exchange chromatography or LC-MS/MS

Best timing

Morning, fasting

Sources. The evidence behind this

Mayo Clinic Laboratories: Amino Acids, Quantitative, Plasma
MedlinePlus: Plasma amino acids

Common questions

Which Aniva panels include this marker?

Amino Acids

These tests assess essential, non-essential, and branched-chain amino acids, plus related metabolites and functional ratios.