Treponema pallidum IgG+IgM Ab Signal/Cutoff

A screening antibody measure for syphilis, reported against a signal cutoff.

Last reviewedJune 16, 2026

Serum

sample type

~5 mL

blood needed

~7 days

results in app

Any time of day

best timing

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On this page

Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

This is the syphilis screening test for Treponema pallidum IgG and IgM antibodies, reported as a Signal-to-Cutoff (S/Co) index instead of a simple positive or negative. The S/Co compares your sample's signal against the test's cutoff line.

A value below 1.0 is non-reactive, and a value at or above 1.0 is reactive. The number reflects how the assay read the sample, not the severity of any infection.

Inflammation & Immune

Reviewed against DGKL reference practice.

Why test this?

Reporting syphilis screening as an S/Co index gives a clear, objective threshold for whether antibodies are present. It supports consistent reading of results across samples.

A non-reactive S/Co is reassuring. A reactive S/Co points to possible syphilis exposure and needs confirmatory testing before any diagnosis or staging.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

This test is reported as a Signal-to-Cutoff (S/Co) index.

S/Co value	Interpretation
Less than 1.0	Non-reactive (negative)
1.0 or above	Reactive, needs confirmation

The cutoff is defined by the assay and may vary by laboratory. A reactive result is not a diagnosis on its own.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

You see where your signal sits relative to the cutoff. An S/Co below 1.0 is non-reactive. An S/Co at or above 1.0 is reactive and leads to confirmatory testing. The value is not a diagnosis and does not indicate infection stage.

What can affect this result?

What can skew the result

Antibodies take time to appear, so very early infection can be missed. Treponemal antibodies often persist for life after treatment, so a reactive S/Co does not by itself mean active disease. Rare false-reactive results are possible. Fasting does not affect the result.

Best interpreted with

Read with confirmatory non-treponemal tests such as RPR or VDRL, with TPPA, and with your clinical and exposure history.

How is this tested?

Sample

Serum

Blood needed

~5 mL

Method

Immunoassay

Best timing

Any time of day

Sources. The evidence behind this

WHO: Syphilis

CDC: Syphilis Testing

Robert Koch-Institut: Syphilis

Common questions

Which Aniva panels include this marker?

STI Screening

These tests screen for the most common sexually transmitted infections.